Description
Phenylephrine Hydrochloride Injection is an alpha-1 adrenergic receptor agonist that is mainly used for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.
Phenylephrine Hydrochloride Injection must be diluted before administration as an intravenous bolus or continuous intravenous infusion to attain the desired concentration:
- Bolus: Dilute with normal saline or 5% dextrose in water.
- Continuous infusion: Dilute with normal saline or 5% dextrose in water.
Parenteral drug products should be inspected visually for particulate matter and discoloration before administration. Do not use the solution if it is colored or cloudy, or if it contains particulate matter. The diluted solution should not be held for more than 4 hours at room temperature or more than 24 hours under refrigerated conditions. Discard any unused portion.
During Phenylephrine Hydrochloride Injection administration:
- Precise intravascular volume depletion.
- Accurate acidosis. Acidosis might reduce the effectiveness of phenylephrine.
Also, there are some recommended dosages if you are using them for the treatment of hypotension during anesthesia. The recommended initial dose is 40 to 100 mcg administered by intravenous bolus. Additional boluses may be administered every 1-2 minutes as needed; not to exceed a total dosage of 200 mcg.
If the blood pressure is below the target goal, start a continuous intravenous infusion with an infusion rate of 10 to 35 mcg/minute; do not exceed 200 mcg/minute. Also, adjust the amount of dosage according to the blood pressure goal.
Uses and Benefits of Phenylephrine Hydrochloride Injection
Some great advantages of Phenylephrine Hydrochloride Injection are:
- It helps treat hypotension during anesthesia.
- The injection is helpful for all blood pressure-related issues.
- It helps increase the blood pressure, and decrease the heart rate.
Side Effects of Phenylephrine Hydrochloride Injection
Some major drawbacks of Phenylephrine Hydrochloride Injection are:
- Redness, pain, and swelling at the injection site.
- Some common side effects like vomiting, stomach pain, headache, nausea, slowed heart rate, neck pain, itching, breathlessness, and high blood pressure.
Conclusion
Phenylephrine Hydrochloride Injection helps treat severe blood pressure problems. If anyone is suffering from any of it, they can consult their doctor and start using this medicine.